- The 2016 NFL Draft marks the second time in franchise history that the team held the 28th overall pick going into the first round. With the only other 28th overall pick, the Chiefs drafted safety Jerome Woods out of the University of Memphis in 1996. In his 10-year career, Woods played in 128 career regular season games with 105 starts.
- The Chiefs traded the 28th overall pick and the club's seventh-round pick (249th overall) to the San Francisco 49ers in exchange for San Francisco's second-round pick (37th overall), fourth-round pick (105th overall) and sixth-round pick (178th overall).
- The Chiefs have traded their first-round pick to the San Francisco 49ers one other time in franchise history, trading the 18th overall pick in the 1993 NFL Draft to the 49ers in exchange for QB Joe Montana, S Dave Whitmore and San Francisco's 1994 third-round selection (96th overall, eventually used on WR Chris Penn).
- The last time the Chiefs traded out of the first round of the NFL Draft was in 2004 when the club sent its first-round pick to the Detroit Lions in exchange for Detroit's second-round pick (36th overall, used on DT Junior Siavii), Detroit's fourth-round pick (105th overall, used on WR Samie Parker) and a fifth-round pick in 2005 (147th overall, eventually used on CB Alphonso Hodge).
- In total, the club has now traded out of the first round of the NFL Draft six times in the draft's modern era (since 1970):
- 2016 (sent to San Francisco for a second-round pick, a fourth-round pick and a sixth-round pick)
- 2004 (sent to Detroit for a second-round pick, a fourth-round pick and a future fifth-round pick)
- 2001 (sent to St. Louis in 2001 QB Trent Green trade)
- 1993 (sent to San Francisco in 1993 QB Joe Montana trade)
- 1975 (sent to Houston in 1974 DE John Matuszak trade)
- 1973 (sent to Chicago in 1972 DT George Seals trade)
- After tonight's trade, the Chiefs own eight total selections in the 2016 NFL Draft:
- 2nd Round – 37th overall (from San Francisco)
- 2nd Round – 59th overall
- 4th Round – 105th overall (from San Francisco)
- 4th Round – 126th overall
- 5th Round – 162nd overall (from Seattle in S Kelcie McCray trade)
- 5th Round – 165th overall
- 6th Round – 178th overall (from San Francisco)
- 6th Round – 203rd overall
- This marks the second time that a team with John Dorsey serving on the personnel staff has not drafted a player in the first round. The last time it happened was in 2008 when the Green Bay Packers traded their first-round pick (30th overall) to the New York Jets in exchange for a second-round pick (36th overall), which was used to select WR Jordy Nelson) and a fourth-round pick (113th overall). The fourth-round selection was eventually traded back to the Jets along with Green Bay's fifth-round selection (162nd overall) for the Jets' fourth-round pick (102nd overall), which was used to draft DE Jeremy Thompson.
- This marks the third time that an Andy Reid-led team did not select a player in the first round of the NFL Draft (2007, 2008 and 2016). In 2007 the Eagles traded their first-round pick (26th overall) to the Dallas Cowboys in exchange for a second-round selection (36th overall) which was used to select QB Kevin Kolb, a third-round pick (87th overall) which was used on LB Stewart Bradley and a fifth-round pick (159th overall) which was used to select S C.J. Gaddis. In 2008 Philadelphia traded its first-round selection (19th overall) to the Carolina Panthers for a second-round pick (43rd overall) which was eventually traded to Minnesota, a fourth-round pick (109th overall) which was used to draft G Mike McGlynn and Carolina's 2009 first-round selection (28th overall), which was eventually traded to the Buffalo Bills as part of the T Jason Peters trade.
