When the Kansas City Chiefs (4-2) take the field on Sunday against the Indianapolis Colts (3-4), they will be doing it without their all-time leading rusher, Jamaal Charles, who was ruled out by head coach Andy Reid on Friday.

Charles has seen limited action in three games this season after working his way back from a torn ACL that cost him most of the 2015 season. He's carried the ball just 12 times for 40 yards with one touchdown.

"It was up and down and we just want to back him off here, and see if we can't get that thing (knee) to settle down," Reid told reporters on Friday of Charles being declared out for Sunday's game. "We're never going to put him out there if it's not right—that's not going to happen. It doesn't matter who the player is."

In Charles' place this year, Spencer Ware has thrived after a breakout campaign last season.

Ware has been one of the league's best dual-threat running backs through the first seven weeks of the NFL season, accumulating 777 total yards from scrimmage, which ranks No. 5 in the NFL.

Looking towards Sunday, the Colts defense has surrendered more than 118 yards rushing per game so far this season, so there's a good chance there will be a heavy diet of Ware on Sunday.

It's also worth mentioning that Colts head coach Chuck Pagano already ruled out defensive end Kendall Langford for Sunday's game. Langford leads the Colts defensive line with 301 snaps played.

Reid also mentioned that right tackle Mitch Schwartz, who hasn't missed a snap of football in his five years in the league and who didn't practice on Wednesday or Thursday with an ankle issue, was out there practicing on Friday.