Quarterback Alex Smith threw for 145 yards, had 78 yards rushing and 3 total touchdowns as the Kansas City Chiefs defeated the Detroit Lions, 45-10, at Wembley Stadium in London, England on Sunday.

After the Lions opened the game with a field goal, the Chiefs scored 38 unanswered points.

Wide receiver De'Anthony Thomas scored first for the Chiefs on a 10-yard jet sweep and Kansas City led 7-3 as the first quarter came to a close.

The Lions opened the second quarter by punting to the Chiefs. On the very next play on first down, Smith ran for the longest rush of his career, a 49-yard run that brought the Chiefs into Lions territory. Smith finished the drive with a 12-yard run for a touchdown to extend the lead to 14-3.

Smith's 78 rushing yards are the most ever by a Chiefs quarterback.

The final Chiefs touchdown of the half came late in the second quarter. Charcandrick West ran 8 yards for the second touchdown of his career.

The Chiefs led 24-3 at the half.

In the second half, Kansas City furthered its lead.  Just like in their opening drive to start the game, the Chiefs scored a touchdown on their first drive of the second half.

Starting on the Kansas City's 39-yard line, Smith worked the offense down to Detroit's 2-yard line. Two yards away from the end zone, Smith hit tight end Travis Kelce on a screen to his left, and Kelce ran it in for his first touchdown since Week 1 and a 31-3 lead.

Wide receiver Jeremy Maclin and fullback Spencer Ware would also get into the mix with touchdowns. Ware's touchdown rushing was the first of his career.

Lions quarterback Matt Stafford was sacked 6 times on the day for a total of 32 yards lost. Linebacker Justin Houston and cornerback Sean Smith each had an interception.

With 45 points, the Chiefs tied the Patriots for the most points ever in an international game.

The Chiefs enter the bye week with a 3-5 record and head to Denver in two weeks to square off with the division-leading Broncos on Sunday, November 15.