The Kansas City Chiefs will aim for their 13th win of the season on Sunday afternoon in a matchup against the Cleveland Browns.

Here are five things to keep in mind heading into game day.

1. Here's a look at the final injury report for both teams.

The Chiefs will likely be without left tackle D.J. Humphries (hamstring) on Sunday, as he's listed as "Doubtful" for the game, and it remains a mystery who will play left tackle in his place.

"The other guys worked in and did a nice job," said Head Coach Andy Reid. "We'll just see where we end up."

UPDATE: The Chiefs downgraded Humphries to "Out" on Saturday.

Kansas City also listed kicker Harrison Butker as "Questionable" for Sunday's game following a four-week stint on Injured Reserve. The Chiefs would need to activate Butker, who returned to practice this week, if he were to play vs. Cleveland. If he can't go, Matthew Wright will handle kicking duties for a third-straight week.

"I'm hesitant to say anything, we'll just see how he is after this practice," Reid said on Friday regarding Butker. "There's a chance [he could play]."

UPDATE: On Saturday, Butker's injury designation was removed and he was activated from IR, indicating that he will play on Sunday.

Additionally, while he won't play on Sunday, wide receiver Hollywood Brown returned to practice on Friday after missing the last several months due a sternoclavicular dislocation.

"He practiced today and did a nice job," Reid said. "It's nice to have him back out there iand going. He got a lot of good work in today…The conditioning part wasn't a problem. He took quite a few reps."

Again, Brown won't play on Sunday, but this marks a major step in his return to action.

As for Cleveland, wide receiver Cedric Tillman (concussion) has already been ruled out for Sunday's game. Tillman, who hasn't played since Week 12, had the third-most receiving yards (with 339) and the most receiving touchdowns (with 3) on the Browns prior to his absence.

An injury status to watch on Sunday will be that of tight end David Njoku (hamstring), who is listed as "Questionable" after missing time in practice over the course of the week. Njoku has 56 receptions for 439 yards and a team-leading five touchdowns this year, so his absence would be a significant one.

Starting left guard Joel Bitonio, who leads the Browns with 911 offensive snaps this season, is also listed as "Questionable" due to a back injury.

Here's a look at the complete injury report for both teams.

2. The Browns' offense has looked completely different under quarterback Jameis Winston.

When looking at the Browns' offense this season, it's really a tale of two different teams.

For example, through the first seven weeks of the season under quarterback Deshaun Watson, Cleveland ranked dead last in total net yards-per-game at 253.9, and third-to-last in net passing yards-per-game (159.6) among all teams. Since Winston took over in Week 8, however, those numbers have changed dramatically.

In that time, which spans six games, Cleveland ranks third in the NFL in net yards-per-game (382) and second in net passing yards-per-game (300.2). The Browns also rank second in the NFL in passing attempts-per-game (43.3) during that time.

Cleveland has racked up at least 400 yards of offense in three of Winston's six starts, and the Browns' 552 total yards against Denver in Week 13 were the third-most for any team in a single game this season.

It's all to say that under Winston, the Browns are throwing the ball a lot, and while he's just 2-4 as Cleveland's starter, it hasn't been without some fireworks.

3. Winston's top target in recent weeks has been wide receiver Jerry Jeudy.

The top beneficiary of Winston's tenure at quarterback has undoubtably been former Broncos' wide receiver Jerry Jeudy, who had just 266 receiving yards through his first seven games of the season. In his six games with Winston, he ranks second in the league (behind only Ja'Marr Chase) with a whopping 678 receiving yards.

He has at least six targets in each of Winston's six games, and on three occasions, he's drawn 11+ targets. Jeudy has often made the most of those passes, too, with at least 60 receiving yards in all six of Winston's starts.

Additionally, Jeudy has done a large chunk of his damage with big plays downfield. His 20 catches (for 342 yards) on throws between 10-19 yards rank second in the league since Week 8, and his 243 yards (on 5 grabs) on throws of 20+ yards downfield also rank second in the NFL during that time.

4. The Chiefs' ability to create takeaways with be critical.

The primary caveat to the Browns' offensive success under Winston is that, in typical gunslinger fashion, the big plays also come with a fair share of turnovers. Cleveland leads the NFL with 13 giveaways since Week 8, and the Browns have turned it over at least three times in each of their last three games.

Looking at the Browns' last two games in particular, Cleveland has racked up 852 yards of total offense (the second-most in the NFL) but also turned it over six times, leading to losses in both contests.

The Chiefs have forced just 10 takeaways this season, which is tied for the third-fewest in the league, but the fact remains that Cleveland's play style will create opportunities for takeaways on Sunday. The key – and maybe the tipping point in the game – will be if Kansas City can take advantage when those opportunities arise.

5. Cleveland's defense owns the No. 2 pressure rate in the NFL this season.

The Browns' defense ranks 26th in the NFL in scoring at 25.8 points-per-game, but despite those overall numbers, a few things still stick out about this group, notably Cleveland's ability to create pressure.

In fact, at 27.7%, the Browns own the No. 2 pressure rate in the NFL this season. Defensive end Myles Garrett, who has 11 sacks and 58 pressures this season, is obviously a big part of that, setting up a compelling matchup for whoever lines up at left tackle for Kansas City.

Another defensive key to watch on Sunday is the Browns' ability to create negative plays. Cleveland, which has forced a league-most 111 negative plays this season, will face a Chiefs' offense that has committed just 53 negative plays (excluding kneel-downs) all year.

What's interesting is that the Browns have been somewhat "boom or bust" in that area, as they've also allowed the second-most plays of 20+ yards in the NFL with 64. That includes 16 runs (the second-most allowed in the league) and 48 passes (the third-most).

So, to put it simply, the Browns' defense is better than their overall numbers may indicate due to its ability to create pressure and negative plays, but the opportunity is also there for Kansas City to rack up some big plays against these guys if the Chiefs can take advantage of them.

It all makes for what should be a much better matchup than the records might suggest, and while the Chiefs locked up the AFC West for a ninth-straight year last week, this is no time to slow down. Kansas City can secure the No. 1 seed in the AFC with at least three wins over the final four weeks (no matter what else happens), and that mission begins on Sunday in Cleveland.