The Kansas City Chiefs have a shot at the best start to a season in franchise history on Sunday as they head to Buffalo to take on the Bills.

Here's what to know about the game.

1. Here's a look at the final injury report for both teams.

There was good and bad news on the injury front for Kansas City this week. On the positive side, wide receiver JuJu Smith-Schuster (hamstring) practiced all week and appears ready to go for Sunday after missing the Chiefs' last three games. Additionally, while neither will play on Sunday, tailback Isiah Pacheco (ankle) and defensive end Charles Omenihu (knee) each returned to practice this week and should be back soon.

In some bad news, however, kicker Harrison Butker injured his knee during practice and was placed on Injured Reserve. In his place, Kansas City signed kicker Spencer Shrader from the New York Jets' practice squad.

As for the Bills, their injury report is a lengthy one. Buffalo will be without rookie wide receiver Keon Coleman (wrist), who ranks second on the team in receiving yards (417) and is tied for the team lead in receiving touchdowns (3). Coleman is averaging 19 yards-per-catch, so his absence is significant.

The Bills will also be without tight end Dalton Kincaid (knee), who ranks second on the team in catches (34) and third in receiving yards (356), meaning that Buffalo will be missing two of its top three pass-catchers on Sunday.

Buffalo is also listing wide receiver Amari Cooper (wrist) as "Questionable" for Sunday. Cooper hasn't played since Week 8 after joining the Bills in a trade earlier this year. Another player to watch for Buffalo is starting right tackle Spencer Brown, who missed time in practice this week due to an ankle injury. Brown is listed as "Questionable" for the game.

2. How will new kicker Spencer Shrader look in his Chiefs debut?

The 25-year-old Shrader appeared in two games for the Jets this season and didn't miss a kick, connecting on two field goal attempts (25 yards and 45 yards) and three extra-point tries. Both of his successful field goal attempts took place last week during the Jets' loss to Arizona.

Prior to joining the Jets, Shrader converted both of his field goal tries during the preseason while with the Indianapolis Colts, which included a 56-yarder. He also made all four of his extra-point tries.

3. The Bills lead the NFL in turnover margin.

Buffalo is a whopping +13 in terms of turnover differential this season, which leads the NFL by a wide margin. The Bills have also either drawn even or won the turnover differential in every game this season. They've forced 19 takeaways over the course of the year (which trails only Minnesota), and they've turned it over themselves just six times, which marks the third-fewest of any team.

A major key to that lofty turnover margin has been the ball security displayed by quarterback Josh Allen, who has committed just six total giveaways (four interceptions and two fumbles) all season. That's a major improvement for Allen, who had 14 giveaways at this point last season.

There is some chance involved here, however, as Allen has committed 13 "turnover worthy plays" this season according to Pro Football Focus, which ranks seventh among all quarterbacks.

So, it'll be up to the Chiefs to turn those turnover worthy plays into takeaways on Sunday.

4. Buffalo's passing attack has relied on big plays after the catch.

The Bills own the No. 3 scoring offense in the NFL at 29 points-per-game, and a big reason behind that success has been their ability to rack up yards after-the-catch. In fact, Buffalo has tallied 59.5% of its passing yards after-the-catch this season, marking the third-highest rate of any team in the NFL.

A primary contributor to those numbers has been wide receiver Khalil Shakir, whose 421 yards after-the-catch this season rank third in the NFL behind only Ja'Marr Chase (451) and Alvin Kamara (430). Shakir also leads all wide receivers with 22 receptions behind the line of scrimmage, and on those catches, he's averaging 8.6 yards-per-reception.

It's all to say that for the Chiefs' defense, getting off blocks and making sure-tackles will be of particular significance against the Bills' offensive scheme.

The good news is Kansas City has now held 30 consecutive opponents under 28 total points, marking the longest streak for any team since the 2000-2001 Philadelphia Eagles. That team was led by Head Coach Andy Reid, and a defensive assistant on that staff – under Defensive Coordinator Jim Johnson – was current Chiefs Defensive Coordinator Steve Spagnuolo.

5. The Chiefs' red zone proficiency will be key on Sunday.

Kanas City's formula for success this season has been dependent on long, taxing drives that condense the number of possessions for both teams. The Chiefs have the fewest offensive possessions in the NFL (89), the most 10-play drives of any team (26), the second-most 10-play scoring drives (22) and the highest average time of possession of any team (33:01). The Chiefs' average scoring drive consumes a league-high 4:45 of clock and takes 9.68 plays (second-most in the NFL).

In turn, the Chiefs' defense has faced the fewest offensive possessions of any team (87), and opponents are averaging the lowest time of possession (26:59) in the NFL.

So, the strategy is clear. Kansas City has shortened games and limited its opponents' opportunities with tremendous success, but it also means that every offensive possession for the Chiefs is valuable, and red zone touchdown efficiency is critical.

The Chiefs excelled at this formula during a three-game stretch from Week 7 through Week 9, scoring touchdowns in the red zone on 11-of-13 opportunities. Kansas City was just 1-for-4 in the red zone last week, however, leaving 12 potential points on the board in a game that came down to the wire.

Kansas City's ability to score touchdowns in the red zone on Sunday will likely determine the outcome, and while it's only mid-November, this game is about as big as a regular season, non-divisional matchup can get during this time of year.

The Chiefs currently possess a two-game lead (in the loss column) over Buffalo for the top seed in the AFC playoff picture, so a win on Sunday would mean a three-game lead and the head-to-head tiebreaker, providing Kansas City with essentially a four-game lead. A loss, meanwhile, would narrow the Chiefs' lead over Buffalo to just one game, and the Bills would possess the tiebreaker.

It all makes for what should be another great chapter in what has become one of the league's best rivalries over the last several years as Kansas City and Buffalo clash yet again.