The Kansas City Chiefs return from the bye on Sunday with a marquee matchup against the San Francisco 49ers.

Here's what to know about the game.

1. Here's a look at the final injury report for both teams.

The Chiefs will be without defensive end Mike Danna (strained pectoral) on Sunday, and in terms of injury designations, wide receiver JuJu Smith-Schuster is listed as "Questionable" due to a hamstring injury.

Despite the designation, however, Head Coach Andy Reid sounded optimistic about Smith-Schuster's chances of playing following practice on Friday.

"I think he'll be fine," Reid said.

As for San Francisco, the 49ers have some significant names on their injury report heading into Sunday's game. At the top of that list is running back Jordan Mason, who doesn't carry an injury designation into Sunday's game despite suffering a shoulder sprain last week.

Mason ranks second in the NFL in rushing yards (609), and for what it's worth, 64% of those yards have taken place after first contact. Additionally, Mason leads the league with 29 broken tackles. So, while Mason will play Sunday, his status will be something to watch throughout the game.

In terms of players who won't take the field, wide receiver Jauan Jennings (hip) won't play on Sunday. Jennings leads the 49ers with 404 receiving yards, 18 first-down receptions and 12 targets on third down this season. His absence is significant.

The 49ers' kicking situation is also worth monitoring. Starting kicker Jake Moody (ankle) and the man San Francisco brought in to replace him, former Chief Matthew Wright (shoulder/back), are both listed as "Out" on Sunday. With that in mind, the 49ers will likely call up former Packers' kicker Anders Carlson, who was perfect on kicks inside the 40 yard-line last season, but from the 40 and beyond, he was just 7-for-13.

2. The Chiefs' defense has excelled at stopping the run and preventing big plays.

Kansas City has held the opposition under 20 points in each of its last three games, and overall, the Chiefs haven't allowed 30 points to an opponent in 27 games (in Super Bowl LVII). Numerous factors have played into that defensive performance, but two specific areas stand out:

• Run Defense: The Chiefs have held all opposing runners (with the exception of quarterback Lamar Jackson) to a combined mark of just 3.14 yards-per-carry this season. Jackson is the only player to top 50 rushing yards against the Chiefs this year, and looking at the quartet of running backs Derrick Henry, Bijan Robinson, J.K. Dobbins and Alvin Kamara specifically, that group has combined to average only 2.5 yards-per-carry vs. Kansas City.

• Preventing Big Plays: Kansas City has also excelled at preventing chunk plays this season, as the Chiefs have yielded the second-fewest plays of 10+ yards (51) and 20+ yards (12) of any team in the NFL.

Those strengths set up a great matchup against San Francisco's offense, which has found significant success in both of those areas. The 49ers rank third in the league in rushing yards-per-game (158) and own the most plays of 20+ yards (31) of any team in the NFL.

Something has to give on Sunday, and whichever team can find success in those specific areas will likely win the game.

3. San Francisco leads the league with 27 red zone drives.

The 49ers' balanced offense (which ranks second in passing and third in rushing) has marched down the field on a regular basis this year, racking up the most red zone drives (27) of any team in the league. For what it's worth, however, San Francisco has often struggled to convert those possessions into touchdowns.

In fact, San Francisco has converted those drives into touchdowns at just a 44.4% clip, which ranks 25th in the league. Additionally, in "goal-to-go" situations, the 49ers are just 7-for-14 in terms of scoring touchdowns.

Those struggles are in stark contrast to the 49ers' success in the red zone last season in which they led the league in touchdown efficiency at 67.2%, and the absence of running back Christian McCaffrey is likely the primary answer as to why. McCaffrey, who has yet to play this season due to injury, scored a whopping 18 red zone touchdowns in 2023. The 49ers have largely managed to make up for his production offensively, but it's fair to say they haven't been the same team in the red zone without him.

Regardless, quarterback Brock Purdy has been excellent this season while spreading the ball around to his multitude of weapons in the passing game. Purdy ranks second in the league in passing yards (1,629) so far this season, and upon a closer look, he's thrived on intermediate throws between 10 and 19 yards from the line of scrimmage. Purdy leads the NFL in attempts (61), completions (42) and passing yards (746) on those throws, which have primarily taken place over the middle of the field.

It's all to say that the Chiefs will need to pay significant attention to the middle of the field on Sunday as they try to slow down Purdy and the 49ers' high-powered offense.

Kansas City's pass-rush may have its opportunities on Sunday, too. Purdy has only been sacked 12 times on the season, but he's been pressured the third-most times (86) of any quarterback in the league. That high pressure total is likely due to his league-high average time to throw of 3.35 seconds, but to his credit, Purdy has only allowed 15.3% of his dropbacks under pressure to end in a sack.

The Chiefs will aim to reverse that trend on Sunday.

4. The 49ers rank 12th in the NFL in scoring defense.

San Francisco is yielding 21.7 points-per-game on average this season due in large part to its 11 takeaways as a team, which rank fifth in the NFL. Edge rusher Nick Bosa also remains among the top pass-rushers in the league as his 35 pressures are the second-most of any player.

On the other hand, the 49ers have struggled on third down (where they rank 23rd) and in the red zone (where they're 19th), and in what has become a bit of a trend, the second half of games has been an issue for San Francisco this year, too. The 49ers have outscored the opposition by 53 points in the first half this season, which ranks second in the NFL, but in the second half, opponents have outscored the 49ers by 21 points.

The Chiefs have outscored opponents at the fourth-best rate in the second half this year (at +31), and if they're to win on Sunday, Kansas City will need to put forth a similar effort.

5. Kansas City racked up 460 yards of offense vs. New Orleans.

The Chiefs piled up 460 yards of offense and operated in Saints' territory on eight of nine drives back in Week 5, but due to a 2-for-7 mark in the red zone, the scoreboard didn't reflect what was otherwise a dominant offensive performance.

A pair of familiar names in running back Kareem Hunt and wide receiver JuJu Smith-Schuster led the way with 247 yards between them, and as a whole, Kansas City recorded its top performance in terms of yards (460), first downs (28), passing yards (331) and yards after-the-catch (250).

The Chiefs have shown an ability to move the football, it's just a matter of finishing in the red zone, and – somewhat ironically – the same can be said for San Francisco. That common thread makes the red zone of the utmost importance on Sunday, and if the Chiefs can find a way to win in that area, Kansas City will have an excellent shot at improving to 6-0 for the first time since 2013.