Patrick Mahomes threw for 295 yards and four touchdowns — including 168 yards and two touchdowns to Travis Kelce — in the Kansas City Chiefs 40-33 win over the Oakland Raiders in Week 13 of the 2018 season.
It was Mahomes' first career start in which the Chiefs were coming off bye and facing a team that played the previous week. Six years later, Mahomes has never lost one of those games. He's a perfect 5-0 entering the next opportunity in Week 7 against the San Francisco 49ers.
Historically in NFL betting, teams are good in those games. They've finished below .500 only once since 2015 (2019) and had a winning percentage of .606 from 2020-23. And while they're typically favored — in approximately 60% of those games — the shorter moneyline odds haven't limited returns. The return on investment in those games is 11.5%.
Against the spread, however, is a different story.
From 2020-23, those teams have an ATS winning percentage of just .471 and ROI of -9.3%. After four straight years in the red (2019-22), they returned to (slight) profitability last year at 0.2%.
As of Monday's NFL odds for the Chiefs-49ers matchup, the Chiefs are favored:
- Spread: Chiefs +1.5 (-110), 49ers -1.5 (-110)
- Moneyline: Chiefs +100, 49ers -120
- Total: Over 46.5 (-110), Under 46.5 (-110)
Visit the BetMGM online sportsbook for more Chiefs-49ers odds and all NFL Week 7 odds. You can also view updated futures, including Chiefs AFC West odds, team playoff odds, and NFL MVP odds.
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